Aaron Oakley, St. Vincent's Institute of Medical Research, Australia
Research Proposal: To Understand the Structure/Function of Human Pi-class Glutathione S-transferases
"The Frevel Scholarship helps people when they need it most --at the start of their careers. As such, it fulfills a vital role in the careers of scientists whose research is oriented toward X-ray diffraction. It is said that success breeds success. In supporting me as a young graduate student, I believe that the Frevel Scholarship made an important contribution to my early career and helped set up later successes."
My first exposure to crystallography was as a Ph.D. student in the Laboratory of Michael Parker at St. Vincent's institute of Medical Research (1994-1997). Learning techniques in macromolecular crystallography, I determined structures of the human Pi-class glutathione transferase in complex with substrates and inhibitors. It was during my time at St. Vincent's that I was awarded what was the ICDD [Ludo Frevel Crystallography] Scholarship.
I have worked in crystallography from my Ph.D. to the present day. I am currently an Associate Professor in the School of Chemistry at the University of Wollongong, where I have established an X-ray laboratory. My current research includes fragment-screening against antibacterial drug targets, structural studies of DNA replication proteins and signaling proteins in muscle contraction.
I have published 65 peer reviewed papers with 1331 citations (assayed by Scopus). I established the macromolecular crystallography lab at University of Wollongong, New South Wales, Australia.
ARC Post-doctoral Fellowship, ARC Future Fellowship, and numerous competitive grants.