PPXRD-6 will be held 20-22 February 2007, Barcelona, Spain Please contact Leah Mooney for further information. mooney@icdd.com Read the summary of PPXRD-5 events The International Centre for Diffraction Data is proud to present the 5th PPXRD right in the heart of the nation's largest concentration of pharmaceutical R&D facilities, New Jersey, U.S.A. This symposium is designed to offer training and create a forum for the exchange cutting edge ideas among those interested in the combined fields of XRD and the pharmaceutical industry. Symposium - $1,200 USD - Student price $299 USD Symposium and Workshop $1,500 USD - Student price - $499 USD CALL FOR PAPERS (12MB PDF - right-click to download) For more information contact: Leah Mooney, Education Coordinator ICDD 12 Campus Boulevard Newtown Square, PA 19073-3273 U.S.A. Telephone: +610-325-9814/Fax: +610-325-9823 E-mail: ppxrd@icdd.com To receive a brochure e-mail your mailing address to ppxrd@icdd.com. Sponsored by:   Media Partners: PPXRD-5 Event Schedule Monday, February 13 Optional Hands-On Workshop - 8:15AM - 5:30PM Characterization of Pharmaceutical Solids: Crystal Studies and XRD Applications Tuesday, February 14 Time Type Title of Paper Speaker & Affiliation 9:00-9:30   WELCOMING REMARKS & INTRODUCTIONS John Faber, International Centre for Diffraction Data, Newtown Square, Pennsylvania, USA   XRPD Structural Techniques (Acquisition and Use of XRPD Data, Indexing, Structure Determination, Rietveld Refinement) Session Chair: Dr. Arnt Kern, Bruker AXS GmbH, Karlsruhe, Germany 9:30-10:15 Invited PHARMACEUTICAL POWDER DIFFRACTION: MAKING MOVIES Bill David, Rutherford Appleton Laboratory, Chilton, Oxfordshire, UK 10:15-10:40 Contributed STRUCTURE SOLUTION AND QUANTITATIVE X-RAY POWDER DIFFRACTION OF PHARMACEUTICALS Gregory Stephenson, Eli Lilly & Company, Indianapolis, Indiana, USA 10:40-11:10 Break     11:10-11:35 Contributed XRD CHARACTERIZATION OF CRYSTALLINITY AND MICROSTRUCTURE OF PHARMACEUTICAL COMPOSITES Luca Lutterotti, Dipartimento Ingegneria dei Materiali e Tecnologie Industriali, Universita' di Trento, Trento, Italy 11:35-12:00 Contributed CLOSE CONTACT PENALTY FUNCTIONS IN DIRECT SPACE METHODS AND ENERGETIC CONSIDERATION IN STRUCTURE REFINEMENT Cikui Liang, Accelrys, San Diego, CA, USA 12:00-1:30 Lunch     Afternoon Complementary Techniques(DSC, TGA, Hot Stage Microscopy, FTIR, Raman, NMR, SEM, AFM, Light Microscopy, XRF, SAXS, SANS) Session Chair: Dr. Gregory Stephenson, Eli Lilly and Company, Indianapolis, Indiana, USA Time Type Title of Paper Speaker & Affiliation 1:30-2:15 Invited COMPLEMENTARY TECHNIQUES FORTHE CHARACTERIZATION OF PHARMACEUTICAL SYSTEMS Raj Suryanarayanan, University of Minnesota, Minnesota USA 2:15-2:40 Contributed COMBINED XRD AND RAMAN COMBINATORIAL SCREENING SYSTEM Bob He, Bruker AXS, Madison, Wisconsin, USA 2:40-3:05 Contributed CHALLENGES IN DETECTING CRYSTALLINE PHASE IN AN AMORPHOUS MATRIX Martha Davidovich, Bristol-Myers Squibb, New Brunswick, New Jersey, USA 3:05-3:35 Break     3:35-4:00 Contributed NEUTRON POWDER DIFFRACTION WITHOUT RESORT TO DEUTERATION: USE IN MOLECULAR STRUCTURE REFINEMENT Kenneth Shankland, CCLRC, Rutherford Appleton Laboratory, Chilton, Oxfordshire, UK 4:00-4:25 Contributed COMBINING MICRO X-RAY FLUORESCENCE AND INFRARED IMAGING SPECTROSCOPIES FOR THE UNDERSTANDING OF MODEL AND COMMERCIAL PHARMACEUTICAL TABLET SYSTEMS Brian Patterson, Los Alamos National Laboratory, Los Alamos, New Mexico, USA Evening (6:00-9:00)                                                    Poster Session Title of Paper Speaker & Affiliation XRPD PATTERN MATCHING: PROBABILITY BASED VERSUS IMAGE COMPARISON Thomas Degen, PANalytical B.V., Almelo, The Netherlands HIGH THROUGHPUT ANALYSIS OF STRUCTURAL GEOMETRIES MINED FROM THE CSD: HOW TO INTERPRET 3000 HITS IN AN AFTERNOON? Arnt Kern, Bruker AXS, Karlsruhe, Germany LOWERING THE LIMITS OF DETECTION OF PHARMACEUTICAL MATERIALS BY POWDER X-RAY DIFFRACTION Brian Litteer, PANalytical Inc., Natick, Massachusettes, USA PDF-4/ORGANICS 2006 REFERENCE POWDER PATTERNS AND THEIR PHARMACEUTICAL APPLICATION Fangling Needham, ICDD, Newtown Square, Pennsylvania, USA CHARACTERIZATION OF THE PHYSICAL FORM OF THE ACTIVE PHARMACEUTICAL INGREDIENT IN INTACT FILM-COATED TABLETS BY X-RAY POWDER DIFFRACTOMETRY Hiroyuki Yamada, University of Minnesota, Minneapolis, Minnesota, USA Wednesday, February 15 Morning Formulation, Product Development, Drug Delivery and Polymorph & Salt Screening Session Chair: Dr. Shawn Yin, Bristol-Myers Squibb, New Brunswick, New Jersey, USA 9:00-9:45 Invited EXPLORING POLYMORPHISM OF MOLECULAR MATERIALS USING HIGH PRESSURE - OPENING UP NEW DIMENSIONS IN POLYMORPH SCREENING Colin Pulham, University of Edinburgh, Edinburgh, Scotland, UK 9:45-10:10 Contributed A NOVEL APPROACH OF USING POWDER X-RAY DIFFRACTION FOR HIGH-THROUGHPUT CRYSTALLIZATION/SALT SCREENING Shawn Yin, Bristol-Myers Squibb Co., New Brunswick, New Jersey, USA 10:10-10:35 Contributed SIMULATED PXRD PATTERNS AS STANDARD REFERENCES IN PHARMACEUTICAL FORM SELECTION Dedong Wu, AstraZeneca Pharmaceuticals LP, Wilmington, Delaware, USA 10:35-11:05 Break     11:05-11:30 Contributed ADVANCED XRPD SYSTEM FOR THE CHARACTERIZATION OF PHARMACEUTICAL COMPOUNDS Vladimir Kogan, PANalytical B.V. & DANNALAB, Almelo, The Netherlands 11:30-11:55 Contributed RESOLVING POLYMORPH CHEMISTRY IN THE CA-O-P-H SYSTEM Timothy Fawcett, ICDD, Newtown Square, Pennsylvania, USA 11:55-1:25 Lunch     Afternoon Con't: Formulation, Product Development, Drug Delivery and Polymorph & Salt Screening Time Type Title of Paper Speaker & Affiliation 1:25-1:50 Contributed USING ANALYTICAL DATA MANAGEMENT SYSTEMS TO ACCELERATE SALT AND POLYMORPH SCREENING Raeann Wu, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA 1:50-2:15 Contributed MISCELLANEOUS PRACTICAL ISSUES FOR PXRD IN A QC LABORATORY Peter Varlashkin, Metrics, Inc., Greenville, North Carolina, USA   Patent and Regulatory Issues Session Chair: Dr. Peter Varlashkin, Metrics, Inc., Greenville, North Carolina, USA Time Type Title of Paper Speaker & Affiliation 2:15-3:00 Invited QUESTION-BASED REVIEW - LINKING REGULATORY EVALUATION OF SOLID STATE PROPERTIES TO PHARMACEUTICAL QUALITY Andre Raw, Food and Drug Adminstration, Rockville, Maryland, USA 3:00-3:30 Break     3:30-3:55 Contributed EQUIPMENT QUALIFICATION Arnt Kern, Bruker AXS, Karlsruhe, Germany 3:55-4:20 Contributed PRINCIPLES IN CLAIMING AND ENFORCING SOLID FORM PATENTS Eyal Barah, SSCI, Inc., West Lafayette, Indiana, USA Thursday, February 16 Morning New Frontiers for XRD in Pharmaceutical R&D Session Chair: Dr. John Faber, International Centre for Diffraction Data, Newtown Square, Pennsylvania, USA Time Type Title of Paper Speaker & Affiliation 9:00-9:45 Invited SYNCHROTRON X-RAY POWDER DIFFRACTION: APPLICATIONS IN MACROMOLECULAR CRYSTALLOGRAPHY Irene Margiolaki, European Synchrotron Radiation Facility(ESRF), Grenoble, France 9:45-10:30 Invited MICRO-SAMPLE X-RAY POWDER DIFFRACTION. APPLICATIONS IN THE PHARMACEUTICAL SCIENCES. Joseph Reibenspies, Texas A & M University, College Station, Texas, USA 10:30-10:50 Break     10:50-11:35 Invited PAT: ANALYSIS OF PROCESS INDUCED DISORDER OF API BY X-RAY POWDER DIFFRACTION Simon Bates, SSCI, Inc., West Lafayette, Indiana, USA 11:35-12:15   Q&A/Closing Remarks   Instructors : Chair: Dr. Jun Han, Novartis Institutes for Biomedical Research, Inc., Cambridge, MA, USA Dr. Detlef Beckers, PANalytical, Almelo, The Netherlands Dr. Harry G. Brittain, Center for Pharmaceutical Physics, Milford, NJ, USA Dr. John Faber, International Centre for Diffraction Data, Newtown Square, PA, USA Dr. Raj Suryanarayanan, University of Minnesota, MN, USA Dr. Shawn Yin, Bristol-Myers Squibb Company, New Brunswick, NJ, USA Morning Basic Theories and Concepts (Monday 13 February - 8:15AM - 12PM) Time Workshop Instructor 8:15 - 9:00 Basics of crystal structure and X-ray diffractometry Dr. Detlef Beckers 9:00 - 9:45 Techniques of Powder X-ray Diffractometry - Instrumentation and Optimization Dr. Detlef Beckers 9:45 - 10:00 BREAK   10:00 - 10:55 Basics of Pharmaceutical Solids Dr. Harry G. Brittain 10:55 - 12:00 Round table and Q&A for Basic theories and Concepts All instructors Afternoon Applications and Case Studies (Monday 13 February - 1PM - 5:30PM) Time Workshop Instructor 1:00 - 1:35 Indexing and structure solution from powder XRD data Dr. John Faber 1:35 - 2:45 Polymorphs Analysis - Qualitative and quantitative analysis of both API and Finished Products Dr. Shawn Yin and Dr. Detlef Beckers 2:45 - 3:00 BREAK   3:00 - 3:50 Application of variable temperature and humidity (environmental) PXRD in Characterizing Pharmaceutical solids Dr. Shawn Yin and Dr. Jun Han 3:50 - 4:35 Characterization of amorphous and crystalline phases by PXRD Dr. Harry G. Brittain 4:35 - 5:30 Round table and Q&A for Application and Case Studies All instructors   Scientific Organizing Committee Dr. John Faber, Chair, International Centre for Diffraction Data , Newtown Square, PA , U.SA Dr. Detlef Beckers, PANalytical , Almelo , The Netherlands Dr. Harry G. Brittain, Center for Pharmaceutical Physics , Milford , NJ , U.S.A. Dr. Julien Giovannini , AstraZeneca , Lund , Sweden Dr. Jun Han, Novartis Institutes for Biomedical Research , Inc., Cambridge , MA , U.S.A. Dr. Arnt Kern, Bruker AXS GmbH , Karlsruhe , Germany Dr. Fangling Needham, International Centre for Diffraction Data , Newtown Square, PA , U.S.A. Dr. Kenneth Shankland, Rutherford Appleton Laboratory, Oxon , U.K. Dr. Peter W. Stephens, State University of New York , Stony Brook , NY , U.S.A. Dr. Gregory A. Stephenson, Eli Lilly and Company , Indianapolis , IN , U.S.A. Dr. Raj Suryanarayanan, University of Minnesota , Minneapolis , MN , U.S.A. Dr. Peter G. Varlashkin, Metrics, Inc., Greenville , NC , U.S.A. Dr. Shawn Yin, Bristol-Myers Squibb Company , New Brunswick , NJ , U.S.A. Location: Marriott Somerset 110 Davidson Avenue Somerset , New Jersey 08873 Tel: +(732) 560-0500 Reservations: +(800) 238-3198 Web: www.marriott.com For more information on New Jersey visit: http://www.state.nj.us/travel/ On-line Reservations Instructions for Somerset Marriott: Go to www.marriott.com/sosnj Scroll down and on the right hand side enter your arrival and departure dates Below that you will see a section for optional information, you can enter your rewards number in the designated box Go to the box labeled Group Code located under the Corporate / Promotional Code box and enter "ICDICDA" Select "Find" - and then select our promotional rate of $104 USD Symposium Format: One-day optional workshop followed by three-day symposium Manufacturer Exhibition Poster Session and reception The symposium talks will be presented in English. General Information: Attire: Attire is informal for most activities Climate: 42 F Time Zone: Eastern Standard Time (EST) Accommodations & Travel: Accommodations: A block of rooms is reserved for symposium participants at the Somerset Marriott, 110 Davidson Avenue , Somerset , NJ 08873 . U.S.A. . Web site: www.marriott.com, Telephone: +(732) 560-0500, Reservations: +(800) 238-3198. The group rate at the hotels is $104.00 per room plus state and local taxes. To make your reservation, please contact the hotel and reference the group name: PPXRD or International Centre for Diffraction Data to receive the discounted group rate. The deadline for hotel reservations is 22 January 2006. You will not be guaranteed a room after that time. Please contact the hotel for the policy on cancellation of reservations. Getting to Marriott Somerset , New Jersey U.S.A. : By Air Airport: Newark - EWR Tel: +973-961-6000 Hotel Direction: 28 mi NE Directions from Airport: Take NJ Turnpike South to Exit 10- I-287 North to Exit 10 ( Easton Ave ) to first light, go left on Davidson Ave Estimated taxi fare: 80 USD (one way) By Train New Brunswick Station (20 mi SE) By Car Use this Marriott link to obtain detailed directions from your location to the Marriott Somerset: http://marriott.com/property/mapandnearbyairports/drivingdirections.mi?marshaCode=sosnj Parking: Complimentary More Information: Cancellation Policy: A 50% refund will be issued, if the cancellation is received by the ICDD in writing no later than 15 January 2006. No refunds will be issued for cancellations received after that date, however, you may transfer your registration to a colleague with advance notice. Exhibitor Information: A commercial exhibition of analytical instrumentation and related products and services is planned during the symposium and during the evening poster session and reception. Organizations interested in exhibiting or sponsorship opportunities, please contact Leah Mooney at mooney@icdd.com or Tel: +610-325-9814. Sponsorships: Opportunities for sponsorship are available to increase your presence at PPXRD. These opportunities include sponsoring or co-sponsoring the evening reception and poster session or daily coffee breaks. The sponsor of the evening reception and poster session will receive first choice of exhibit location, banner on the PPXRD web page with link to your web site, link to your web site from our electronic e-mail marketing campaigns and space to place a full-page advertisement in the symposium Book of Abstracts.   READ THE PPXRD-4 SYMPOSIUM SUMMARY The International Centre for Diffraction Data was proud to present the 4th PPXRD in the spectacular city of Barcelona, Spain located on the Mediterranean Sea. This symposium was designed to create a forum for discussion and the exchange of knowledge and cutting edge ideas among those interested in the combined fields of XRD and the pharmaceutical industry. These pages are maintained for archival purposes - the Symposium was a great success. . Information on Past PPXRD Symposiums PPXRD-4, February 21-24, 2005 PPXRD-3, February 23-25, 2004 PPXRD-2, December 9-12, 2002 PPXRD-1 - September 27-29, 1999 PPXRD-5 | Program | Register | Details | Abstracts | Exhibitors | Contact