• Basics of crystal structure and X-ray diffractometry
  • Techniques of Powder X-ray Diffractometry - Instrumentation and Optimization
  • Basics of Pharmaceutical Solids
  • Indexing and structure solution from powder XRD data
  • Polymorphs Analysis - Qualitative and quantitative analysis of both API and Finished Products
  • Application of variable temperature and humidity (environmental) PXRD in Characterizing Pharmaceutical solids.
  • Characterization of amorphous and crystalline phases by PXRD

See Invited Speaker Bios

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PPXRD-5 Event Schedule

Monday, February 13

Optional Hands-On Workshop - 8:15AM - 5:30PM
Characterization of Pharmaceutical Solids: Crystal Studies and XRD Applications

Tuesday, February 14

Time Type Title of Paper Speaker & Affiliation
9:00-9:30   WELCOMING REMARKS & INTRODUCTIONS John Faber, International Centre for Diffraction Data, Newtown Square, Pennsylvania, USA
  XRPD Structural Techniques (Acquisition and Use of XRPD Data, Indexing, Structure Determination, Rietveld Refinement)
Session Chair: Dr. Arnt Kern, Bruker AXS GmbH, Karlsruhe, Germany
9:30-10:15 Invited PHARMACEUTICAL POWDER DIFFRACTION: MAKING MOVIES Bill David, Rutherford Appleton Laboratory, Chilton, Oxfordshire, UK
10:15-10:40 Contributed STRUCTURE SOLUTION AND QUANTITATIVE X-RAY POWDER DIFFRACTION OF PHARMACEUTICALS Gregory Stephenson, Eli Lilly & Company, Indianapolis, Indiana, USA
10:40-11:10 Break    
11:10-11:35 Contributed XRD CHARACTERIZATION OF CRYSTALLINITY AND MICROSTRUCTURE OF PHARMACEUTICAL COMPOSITES Luca Lutterotti, Dipartimento Ingegneria dei Materiali e Tecnologie Industriali, Universita' di Trento, Trento, Italy
11:35-12:00 Contributed CLOSE CONTACT PENALTY FUNCTIONS IN DIRECT SPACE METHODS AND ENERGETIC CONSIDERATION IN STRUCTURE REFINEMENT Cikui Liang, Accelrys, San Diego, CA, USA
12:00-1:30 Lunch    


Afternoon Complementary Techniques(DSC, TGA, Hot Stage Microscopy, FTIR, Raman, NMR, SEM, AFM, Light Microscopy, XRF, SAXS, SANS)
Session Chair: Dr. Gregory Stephenson, Eli Lilly and Company, Indianapolis, Indiana, USA
Time Type Title of Paper Speaker & Affiliation
1:30-2:15 Invited COMPLEMENTARY TECHNIQUES FORTHE CHARACTERIZATION OF PHARMACEUTICAL SYSTEMS Raj Suryanarayanan, University of Minnesota, Minnesota USA
2:15-2:40 Contributed COMBINED XRD AND RAMAN COMBINATORIAL SCREENING SYSTEM Bob He, Bruker AXS, Madison, Wisconsin, USA
2:40-3:05 Contributed CHALLENGES IN DETECTING CRYSTALLINE PHASE IN AN AMORPHOUS MATRIX Martha Davidovich, Bristol-Myers Squibb, New Brunswick, New Jersey, USA
3:05-3:35 Break    
3:35-4:00 Contributed NEUTRON POWDER DIFFRACTION WITHOUT RESORT TO DEUTERATION: USE IN MOLECULAR STRUCTURE REFINEMENT Kenneth Shankland, CCLRC, Rutherford Appleton Laboratory, Chilton, Oxfordshire, UK
4:00-4:25 Contributed COMBINING MICRO X-RAY FLUORESCENCE AND INFRARED IMAGING SPECTROSCOPIES FOR THE UNDERSTANDING OF MODEL AND COMMERCIAL PHARMACEUTICAL TABLET SYSTEMS Brian Patterson, Los Alamos National Laboratory, Los Alamos, New Mexico, USA


Evening (6:00-9:00)                                                    Poster Session
Title of Paper Speaker & Affiliation
XRPD PATTERN MATCHING: PROBABILITY BASED VERSUS IMAGE COMPARISON Thomas Degen, PANalytical B.V., Almelo, The Netherlands
ANALYSES OF PHARMACEUTICAL FORMULATIONS Timothy Fawcett, ICDD, Newtown Square, Pennsylvania, USA
HIGH THROUGHPUT ANALYSIS OF STRUCTURAL GEOMETRIES MINED FROM THE CSD: HOW TO INTERPRET 3000 HITS IN AN AFTERNOON? Arnt Kern, Bruker AXS, Karlsruhe, Germany
LOWERING THE LIMITS OF DETECTION OF PHARMACEUTICAL MATERIALS BY POWDER X-RAY DIFFRACTION Brian Litteer, PANalytical Inc., Natick, Massachusettes, USA
PDF-4/ORGANICS 2006 REFERENCE POWDER PATTERNS AND THEIR PHARMACEUTICAL APPLICATION Fangling Needham, ICDD, Newtown Square, Pennsylvania, USA
CHARACTERIZATION OF THE PHYSICAL FORM OF THE ACTIVE PHARMACEUTICAL INGREDIENT IN INTACT FILM-COATED TABLETS BY X-RAY POWDER DIFFRACTOMETRY Hiroyuki Yamada, University of Minnesota, Minneapolis, Minnesota, USA


Wednesday, February 15

Morning Formulation, Product Development, Drug Delivery and Polymorph & Salt Screening
Session Chair: Dr. Shawn Yin, Bristol-Myers Squibb, New Brunswick, New Jersey, USA
9:00-9:45 Invited EXPLORING POLYMORPHISM OF MOLECULAR MATERIALS USING HIGH PRESSURE - OPENING UP NEW DIMENSIONS IN POLYMORPH SCREENING Colin Pulham, University of Edinburgh, Edinburgh, Scotland, UK
9:45-10:10 Contributed A NOVEL APPROACH OF USING POWDER X-RAY DIFFRACTION FOR HIGH-THROUGHPUT CRYSTALLIZATION/SALT SCREENING Shawn Yin, Bristol-Myers Squibb Co., New Brunswick, New Jersey, USA
10:10-10:35 Contributed SIMULATED PXRD PATTERNS AS STANDARD REFERENCES IN PHARMACEUTICAL FORM SELECTION Dedong Wu, AstraZeneca Pharmaceuticals LP, Wilmington, Delaware, USA
10:35-11:05 Break    
11:05-11:30 Contributed ADVANCED XRPD SYSTEM FOR THE CHARACTERIZATION OF PHARMACEUTICAL COMPOUNDS Vladimir Kogan, PANalytical B.V. & DANNALAB, Almelo, The Netherlands
11:30-11:55 Contributed RESOLVING POLYMORPH CHEMISTRY IN THE CA-O-P-H SYSTEM Timothy Fawcett, ICDD, Newtown Square, Pennsylvania, USA
11:55-1:25 Lunch    


Afternoon Con't: Formulation, Product Development, Drug Delivery and Polymorph & Salt Screening
Time Type Title of Paper Speaker & Affiliation
1:25-1:50 Contributed USING ANALYTICAL DATA MANAGEMENT SYSTEMS TO ACCELERATE SALT AND POLYMORPH SCREENING Raeann Wu, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA
1:50-2:15 Contributed MISCELLANEOUS PRACTICAL ISSUES FOR PXRD IN A QC LABORATORY Peter Varlashkin, Metrics, Inc., Greenville, North Carolina, USA
  Patent and Regulatory Issues
Session Chair: Dr. Peter Varlashkin, Metrics, Inc., Greenville, North Carolina, USA
Time Type Title of Paper Speaker & Affiliation
2:15-3:00 Invited QUESTION-BASED REVIEW - LINKING REGULATORY EVALUATION OF SOLID STATE PROPERTIES TO PHARMACEUTICAL QUALITY Andre Raw, Food and Drug Adminstration, Rockville, Maryland, USA
3:00-3:30 Break    
3:30-3:55 Contributed EQUIPMENT QUALIFICATION Arnt Kern, Bruker AXS, Karlsruhe, Germany
3:55-4:20 Contributed PRINCIPLES IN CLAIMING AND ENFORCING SOLID FORM PATENTS Eyal Barah, SSCI, Inc., West Lafayette, Indiana, USA


Thursday, February 16

Morning New Frontiers for XRD in Pharmaceutical R&D
Session Chair: Dr. John Faber, International Centre for Diffraction Data, Newtown Square, Pennsylvania, USA
Time Type Title of Paper Speaker & Affiliation
9:00-9:45 Invited SYNCHROTRON X-RAY POWDER DIFFRACTION: APPLICATIONS IN MACROMOLECULAR CRYSTALLOGRAPHY Irene Margiolaki, European Synchrotron Radiation Facility(ESRF), Grenoble, France
9:45-10:30 Invited MICRO-SAMPLE X-RAY POWDER DIFFRACTION. APPLICATIONS IN THE PHARMACEUTICAL SCIENCES. Joseph Reibenspies, Texas A & M University, College Station, Texas, USA
10:30-10:50 Break    
10:50-11:35 Invited PAT: ANALYSIS OF PROCESS INDUCED DISORDER OF API BY X-RAY POWDER DIFFRACTION Simon Bates, SSCI, Inc., West Lafayette, Indiana, USA
11:35-12:15   Q&A/Closing Remarks  






Information on Past PPXRD Symposiums
PPXRD-4, February 21-24, 2005
PPXRD-3, February 23-25, 2004
PPXRD-2, December 9-12, 2002
PPXRD-1 - September 27-29, 1999

PPXRD-5 | Program | Register | Details | Abstracts | Exhibitors | Contact

Information on Past PPXRD Symposiums
PPXRD-4, February 21-24, 2005
PPXRD-3, February 23-25, 2004
PPXRD-2, December 9-12, 2002
PPXRD-1 - September 27-29, 1999

PPXRD-5 | Program | Register | Details | Abstracts | Exhibitors | Contact

 

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