MONDAY

WORKSHOP - 22 February 2010

UNDERSTANDING AMORPHOUS PHARMACEUTICAL MATERIALS
Organizer: Shawn Yin
Bristol-Myers Squibb Company, New Brunswick, NJ, shawn.yin@bms.com

8:30-9:00 am

Introduction – Amorphous Materials and Pharmaceutical Applications

Shawn Yin
Bristol-Myers Squibb Company, New Brunswick, NJ

9:00-10:00 am

Amorphous Basics - PRESENTATION

Ann Newman
Seventh Street Development Group, Lafayette, IN

10:00-10:30 am

BREAK

10:30-12:00 pm

How to Prepare Amorphous API

Michael Pikal
University of Connecticut, Storrs, CT

12:00-1:00 pm  

LUNCH - Attendees are on their own for lunch

1:00-2:30 pm   

Using PXRD for Amorphous Materials

Simon Bates
Aptuit Consulting, West Lafayette, IN

2:30-3:15 pm

Using ssNMR and Other Techniques for Amorphous Materials

Eric Munson
University of Kansas, Lawrence, KS

3:15-3:45 pm

BREAK

3:45-4:30 pm

Using Thermal Techniques for Amorphous Materials

Michael Pikal
University of Connecticut, Storrs, CT

4:30-5:30 pm 

Optional Panel Discussion

All instructors

TUESDAY

SYMPOSIUM - 23 February 2010

8:30-8:45 am

WELCOMING REMARKS & INTRODUCTIONS

Cyrus E. Crowder
International Centre for Diffraction Data, Newtown Square, PA

PLENARY SESSION: PATENT AND REGULATORY ISSUES
Chair: Cyrus E. Crowder
International Centre for Diffraction Data, Newtown Square, PA, crowder@icdd.com

8:45-10:00 am

INVITED - Patenting Crystalline Forms of Pharmaceuticals – Using Solid State Science to Claim Form & Substance - PRESENTATION

Jeffrey A. Lindeman
J.A. Lindeman & Co. PLLC, McLean, VA

10:00-10:30 am

BREAK – exhibits open

XRPD STRUCTURAL TECHNIQUES
(Acquisition and Use of XRPD Data, Indexing, Structure Determination, Rietveld Refinement)
Chair: Hideo Toraya
Rigaku Corporation, Tokyo, Japan, toraya@rigaku.co.jp

10:30-11:30 am

INVITED - Accurate Powder Structural Study of Pharmaceuticals Using Maximum Entropy Method - ABSTRACT

Eiji Nishibori
Nagoya University, Nagoya, Japan

11:30-12:00 pm

Ab Initio Crystal Structure Determination of Two Polymorphic Modifications of an Anesthetic Agent, Tetracaine Hydrochloride, Using a Combination of Molecular Modeling and Synchrotron X-ray Powder Diffraction Techniques - PRESENTATION

Robert Papoular
Leon Brillouin Laboratory, Gif-sur-Yvette, France

12:00-1:15 pm

LUNCH – Attendees are on their own for lunch. Exhibits open.

COMPLEMENTARY TECHNIQUES
Chair: Shawn Yin
Bristol-Myers Squibb Company, New Brunswick, NJ shawn.yin@bms.com

1:15-2:15 pm

INVITED - Solid-State Analysis of Pharmaceuticals: Solid-State NMR and PXRD - ABSTRACT

Eric Munson
University of Kansas, Lawrence, KS

2:15-2:45 pm

PXRD with Raman Spectroscopy, DSC and IR DATA - PRESENTATION

Chris Gilmore
University of Glasgow, Glasgow, UK

2:45-3:15 pm

Integrated Hyperspectral Imaging for Comprehensive Materials Characterization - ABSTRACT

Eunah Lee
Horiba Jobin Yvon, Inc., Edison, NJ

3:15-3:45 pm

BREAK - exhibits open

AMORPHOUS, ACTIVATED AND NANOMATERIALS
Chair: Cyrus E. Crowder
International Centre for Diffraction Data, Newtown Square, PA, crowder@icdd.com

3:45-4:45 pm

INVITED - The Amorphous State: A Structural Perspective - PRESENTATION

Simon Bates
Aptuit Consulting, West Lafayette, IN

6:00-8:00 pm

POSTER SESSION, RECEPTION, EXHIBITS

An evening reception and poster session of submitted papers was held in the exhibit hall.

WEDNESDAY

SYMPOSIUM - 24 February 2010

FORMULATION & PRODUCT DEVELOPMENT
Chair: Shawn Yin
Bristol-Myers Squibb Company, New Brunswick, NJ shawn.yin@bms.com

8:30-9:30 am

INVITED - Drug Product Characterization: What Form Do I Have? - PRESENTATION

Ann Newman
Seventh Street Development Group, Lafayette, IN

9:30-10:00 am

Successful Material Identification - ABSTRACT

Timothy Fawcett
International Centre for Diffraction Data, Newtown Square, PA

10:00-10:30 am

XRPD Characterization of Pharmaceutical Solids - Quantitative Phase Analysis and Lower Limits of Detection - ABSTRACT

Arnt Kern
Bruker AXS, Inc., Karlsruhe, Germany

10:30-11:00 am

BREAK – exhibits open

11:00-11:30 am

PXRD Investigation of Changes in Dehydration Behavior of 7-Methoxy-1-Methyl-5-(4-(Trifluoromethyl)Phenyl)-[1,2,4]Triazolo[4,3-A]Quinolin-4-Amine Hydrate After Micronization - PRESENTATION

Feirong Kang
GlaxoSmithKline, King of Prussia, PA

11:30-12:00 pm

X-ray Powder Diffraction Database Tools for the Pharmaceutical Scientist: New Capabilities - PRESENTATION

Cyrus E. Crowder
International Centre for Diffraction Data, Newtown Square, PA

12:00-12:30 pm

Quantification of Indomethacin-Saccharin Cocrystals by Powder X-ray Diffraction - ABSTRACT

Sitaram Velaga
Luleå University of Technology, Luleå, Sweden

12:30-1:30 pm

LUNCH – exhibits open

NEW FRONTIERS IN XRD IN PHARMACEUTICAL R&D
Chairs: Fangling Needham and Timothy Fawcett
International Centre for Diffraction Data, Newtown Square, PA, needham@icdd.com; fawcett@icdd.com
Raj Suryanarayanan
University of Minnesota, Minneapolis, MN, surya001@tc.umn.edu

1:30-2:30 pm

INVITED - The New World of Materials Science & Engineering: Nano & Bio Technology - ABSTRACT

Robert Snyder
Georgia Institute of Technology, Atlanta, GA

2:30-3:30 pm

INVITED - Structure Studies of Disordered Pharmaceutical Materials by High-Energy X-ray Diffraction and Atomic Pair Distribution Function Analysis - PRESENTATION

Valeri Petkov
Central Michigan University, Mt. Pleasant, MI

3:30-4:00 pm

BREAK – last chance to view exhibits

4:00-4:30 pm

Easy Access to Synchrotron Powder Diffraction on Pharmaceuticals - PRESENTATION

Brian H. Toby
APS, Argonne National Laboratory, Argonne, IL

4:30-5:00 pm

The Use of Field-Portable pXRD for the Rapid Identification of Counterfeit Pharmaceutical Products and Subsequent Excipient Identification and Quantification- PRESENTATION

David Blake
NASA Ames Research Center, Moffett Field, CA

5:00-5:30 pm

Geometry, Polarization and Absorption Corrections for Two-Dimensional XRD - PRESENTATION

Bob B. He
Bruker AXS, Inc., Madison, WI

THURSDAY

SYMPOSIUM - 25 February 2010

POLYMORPH & SALT SCREENING
Chair: Timothy Fawcett
International Centre for Diffraction Data, Newtown Square, PA, fawcett@icdd.com

8:30-9:00 am

Analysis of Amorphous Phase in Highly Crystalline API by Powder X-ray Diffraction and DSC - ABSTRACT

Beth Sarsfield
Bristol-Myers Squibb, New Brunswick, NJ

9:00-9:30 am

Polymorphs in PDF-4/Organics 2010 - PRESENTATION

Fangling Needham
International Centre for Diffraction Data, Newtown Square, PA

9:30-11:30 am

ROUND TABLE & DISCUSSION

All PPXRD-9 Workshop & Symposium participants welcome