PPXRD-15 Tentative Program*
18-20 August 2017, Hyderabad, India

WORKSHOP
Friday, 18 August

Powder XRD Applications for Pharmaceutical Product Development
Organizers & Instructors:
R. Suryanarayanan, University of Minnesota, Minneapolis, MN, USA, surya001@umn.edu
T. Blanton, International Centre for Diffraction Data, Newtown Square, PA, USA, tblanton@icdd.com
G. de Delgado, University de Los Andes, Merida, Venezuela, diaz@ula.ve
D. Beckers, PANalytical, Almelo, The Netherlands, detlef.beckers@panalytical.com

In the context of preformulation studies, X-ray powder diffraction (XRD) has been extensively used to identify different physical forms of drugs and excipients. The application of XRD for pharmaceutical characterization will be described with several representative examples, followed by the use of XRD to identify and characterize multiple crystalline phases in a complex matrix.  In drug products XRD can be used to simultaneously characterize crystalline drugs and excipients and the application of this technique in different dosage forms including tablets and lyophilized solids will be demonstrated. During pharmaceutical processing, there is the potential for processing-induced phase transformations which can have profound implications on the final product performance.  As representative examples, phase transitions during the manufacture of tablets and freeze-dried products will be discussed.  Recent advances in instrumentation and software have enabled quantitative phase analyses in complex, multicomponent systems with enhanced limits of detection and quantification. Moreover, selective subtraction of the contribution of formulation components (for example, high concentration of excipients) can enhance analyte sensitivity and examples will be provided.  The course participants will get a 30 day license of the ICDD PDF-4+ database and associated software for use during the workshop and later evaluation. There will a demonstration of data mining, phase identification and other relevant searches of interest to the pharmaceutical community.

SESSIONS
Saturday - Sunday, 19-20 August

Qualitative Phase Analysis with XRPD
Co-chairs: D. Beckers, PANalytical, Almelo, The Netherlands, detlef.beckers@panalytical.com
F. Gozzo, Excelsus Structural Solutions sprl, Brussels, Belgium, fabia.gozzo@excels.us
Invited Speaker: R. Suryanarayanan, University of Minnesota, Minneapolis, MN, USA

Quantitative Phase Analysis: Single Peak, Whole-Pattern Methods and Beyond
Co-chairs: F. Gozzo, Excelsus Structural Solutions sprl, Brussels, Belgium, fabia.gozzo@excels.us
D. Beckers, PANalytical, Almelo, The Netherlands, detlef.beckers@panalytical.com
Invited Speaker: S.R. Byrn, Purdue University, West Lafayette, IN, USA

Amorphous, Mesomorphous and Nano Materials
Chair: A. Kern, Bruker AXS GmbH, Karlsruhe, Germany, arnt.kern@bruker.com
Invited Speakers: R. Frison, Excelsus Structural Solutions (Swiss) AG & University of Zurich, Switzerland
M. Leoni, University di Trento, Trento, Italy

Non-Ambient Powder X-ray Diffraction
Chair: T. Blanton, International Centre for Diffraction Data, Newtown Square, PA, USA
Invited Speaker: R. Suryanarayanan, University of Minnesota, Minneapolis, MN, USA

New Developments/Complementary Techniques
Chair: K. Saito, Rigaku Europe SE, Ettlingen, Germany, keisuke.saito@rigaku.com
Invited Speaker: H. Toraya, Rigaku Corporation, Tokyo, Japan

Formulation and Product Development
Chair: T.N. Guru Row, Indian Institute of Science, India
Invited Speaker: V. Peddy, Dr. Reddy's Laboratories Ltd., India

Polymorph, Salt and Co-crystal Screening
Chair: G. de Delgado, University de Los Andes, Merida, Venezuela, diaz@ula.ve
Invited speakers: A. Nangia, Director of the National Chemical Laboratory, Pune, India
T.N. Guru Row, Indian Institute of Science, India

Crystal Structure Prediction, Elucidation and Verification from Powder Diffraction Data
Chair: J. Kaduk, Poly Crystallography, Inc., Naperville, IL, USA, kaduk@polycrystallography.com
Invited Speaker: F.F. Ferreira, Universidade Federal do ABC – UFABC, Brazil

*Sessions subject to change depending on abstract submissions. Invited speakers to be announced in December.