PPXRD-6 will be held
20-22 February 2007, Barcelona, Spain

Please contact Leah Mooney
for further information.
mooney@icdd.com

Read the summary of PPXRD-5 events

The International Centre for Diffraction Data is proud to present the 5th PPXRD right in the heart of the nation's largest concentration of pharmaceutical R&D facilities, New Jersey, U.S.A. This symposium is designed to offer training and create a forum for the exchange cutting edge ideas among those interested in the combined fields of XRD and the pharmaceutical industry.

Symposium - $1,200 USD - Student price $299 USD
Symposium and Workshop $1,500 USD - Student price - $499 USD

CALL FOR PAPERS (12MB PDF - right-click to download)

For more information contact:
Leah Mooney, Education Coordinator
ICDD
12 Campus Boulevard
Newtown Square, PA 19073-3273 U.S.A.
Telephone: +610-325-9814/Fax: +610-325-9823
E-mail: ppxrd@icdd.com

To receive a brochure e-mail your mailing address to ppxrd@icdd.com.

Sponsored by:

 

Media Partners:


PPXRD-5 Event Schedule

Monday, February 13

Optional Hands-On Workshop - 8:15AM - 5:30PM
Characterization of Pharmaceutical Solids: Crystal Studies and XRD Applications


Tuesday, February 14

Time Type Title of Paper Speaker & Affiliation
9:00-9:30   WELCOMING REMARKS & INTRODUCTIONS John Faber, International Centre for Diffraction Data, Newtown Square, Pennsylvania, USA
  XRPD Structural Techniques (Acquisition and Use of XRPD Data, Indexing, Structure Determination, Rietveld Refinement)
Session Chair: Dr. Arnt Kern, Bruker AXS GmbH, Karlsruhe, Germany
9:30-10:15 Invited PHARMACEUTICAL POWDER DIFFRACTION: MAKING MOVIES Bill David, Rutherford Appleton Laboratory, Chilton, Oxfordshire, UK
10:15-10:40 Contributed STRUCTURE SOLUTION AND QUANTITATIVE X-RAY POWDER DIFFRACTION OF PHARMACEUTICALS Gregory Stephenson, Eli Lilly & Company, Indianapolis, Indiana, USA
10:40-11:10 Break    
11:10-11:35 Contributed XRD CHARACTERIZATION OF CRYSTALLINITY AND MICROSTRUCTURE OF PHARMACEUTICAL COMPOSITES Luca Lutterotti, Dipartimento Ingegneria dei Materiali e Tecnologie Industriali, Universita' di Trento, Trento, Italy
11:35-12:00 Contributed CLOSE CONTACT PENALTY FUNCTIONS IN DIRECT SPACE METHODS AND ENERGETIC CONSIDERATION IN STRUCTURE REFINEMENT Cikui Liang, Accelrys, San Diego, CA, USA
12:00-1:30 Lunch    


Afternoon Complementary Techniques(DSC, TGA, Hot Stage Microscopy, FTIR, Raman, NMR, SEM, AFM, Light Microscopy, XRF, SAXS, SANS)
Session Chair: Dr. Gregory Stephenson, Eli Lilly and Company, Indianapolis, Indiana, USA
Time Type Title of Paper Speaker & Affiliation
1:30-2:15 Invited COMPLEMENTARY TECHNIQUES FORTHE CHARACTERIZATION OF PHARMACEUTICAL SYSTEMS Raj Suryanarayanan, University of Minnesota, Minnesota USA
2:15-2:40 Contributed COMBINED XRD AND RAMAN COMBINATORIAL SCREENING SYSTEM Bob He, Bruker AXS, Madison, Wisconsin, USA
2:40-3:05 Contributed CHALLENGES IN DETECTING CRYSTALLINE PHASE IN AN AMORPHOUS MATRIX Martha Davidovich, Bristol-Myers Squibb, New Brunswick, New Jersey, USA
3:05-3:35 Break    
3:35-4:00 Contributed NEUTRON POWDER DIFFRACTION WITHOUT RESORT TO DEUTERATION: USE IN MOLECULAR STRUCTURE REFINEMENT Kenneth Shankland, CCLRC, Rutherford Appleton Laboratory, Chilton, Oxfordshire, UK
4:00-4:25 Contributed COMBINING MICRO X-RAY FLUORESCENCE AND INFRARED IMAGING SPECTROSCOPIES FOR THE UNDERSTANDING OF MODEL AND COMMERCIAL PHARMACEUTICAL TABLET SYSTEMS Brian Patterson, Los Alamos National Laboratory, Los Alamos, New Mexico, USA


Evening (6:00-9:00)                                                    Poster Session
Title of Paper Speaker & Affiliation
XRPD PATTERN MATCHING: PROBABILITY BASED VERSUS IMAGE COMPARISON Thomas Degen, PANalytical B.V., Almelo, The Netherlands
HIGH THROUGHPUT ANALYSIS OF STRUCTURAL GEOMETRIES MINED FROM THE CSD: HOW TO INTERPRET 3000 HITS IN AN AFTERNOON? Arnt Kern, Bruker AXS, Karlsruhe, Germany
LOWERING THE LIMITS OF DETECTION OF PHARMACEUTICAL MATERIALS BY POWDER X-RAY DIFFRACTION Brian Litteer, PANalytical Inc., Natick, Massachusettes, USA
PDF-4/ORGANICS 2006 REFERENCE POWDER PATTERNS AND THEIR PHARMACEUTICAL APPLICATION Fangling Needham, ICDD, Newtown Square, Pennsylvania, USA
CHARACTERIZATION OF THE PHYSICAL FORM OF THE ACTIVE PHARMACEUTICAL INGREDIENT IN INTACT FILM-COATED TABLETS BY X-RAY POWDER DIFFRACTOMETRY Hiroyuki Yamada, University of Minnesota, Minneapolis, Minnesota, USA


Wednesday, February 15

Morning Formulation, Product Development, Drug Delivery and Polymorph & Salt Screening
Session Chair: Dr. Shawn Yin, Bristol-Myers Squibb, New Brunswick, New Jersey, USA
9:00-9:45 Invited EXPLORING POLYMORPHISM OF MOLECULAR MATERIALS USING HIGH PRESSURE - OPENING UP NEW DIMENSIONS IN POLYMORPH SCREENING Colin Pulham, University of Edinburgh, Edinburgh, Scotland, UK
9:45-10:10 Contributed A NOVEL APPROACH OF USING POWDER X-RAY DIFFRACTION FOR HIGH-THROUGHPUT CRYSTALLIZATION/SALT SCREENING Shawn Yin, Bristol-Myers Squibb Co., New Brunswick, New Jersey, USA
10:10-10:35 Contributed SIMULATED PXRD PATTERNS AS STANDARD REFERENCES IN PHARMACEUTICAL FORM SELECTION Dedong Wu, AstraZeneca Pharmaceuticals LP, Wilmington, Delaware, USA
10:35-11:05 Break    
11:05-11:30 Contributed ADVANCED XRPD SYSTEM FOR THE CHARACTERIZATION OF PHARMACEUTICAL COMPOUNDS Vladimir Kogan, PANalytical B.V. & DANNALAB, Almelo, The Netherlands
11:30-11:55 Contributed RESOLVING POLYMORPH CHEMISTRY IN THE CA-O-P-H SYSTEM Timothy Fawcett, ICDD, Newtown Square, Pennsylvania, USA
11:55-1:25 Lunch    


Afternoon Con't: Formulation, Product Development, Drug Delivery and Polymorph & Salt Screening
Time Type Title of Paper Speaker & Affiliation
1:25-1:50 Contributed USING ANALYTICAL DATA MANAGEMENT SYSTEMS TO ACCELERATE SALT AND POLYMORPH SCREENING Raeann Wu, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA
1:50-2:15 Contributed MISCELLANEOUS PRACTICAL ISSUES FOR PXRD IN A QC LABORATORY Peter Varlashkin, Metrics, Inc., Greenville, North Carolina, USA
  Patent and Regulatory Issues
Session Chair: Dr. Peter Varlashkin, Metrics, Inc., Greenville, North Carolina, USA
Time Type Title of Paper Speaker & Affiliation
2:15-3:00 Invited QUESTION-BASED REVIEW - LINKING REGULATORY EVALUATION OF SOLID STATE PROPERTIES TO PHARMACEUTICAL QUALITY Andre Raw, Food and Drug Adminstration, Rockville, Maryland, USA
3:00-3:30 Break    
3:30-3:55 Contributed EQUIPMENT QUALIFICATION Arnt Kern, Bruker AXS, Karlsruhe, Germany
3:55-4:20 Contributed PRINCIPLES IN CLAIMING AND ENFORCING SOLID FORM PATENTS Eyal Barah, SSCI, Inc., West Lafayette, Indiana, USA


Thursday, February 16

Morning New Frontiers for XRD in Pharmaceutical R&D
Session Chair: Dr. John Faber, International Centre for Diffraction Data, Newtown Square, Pennsylvania, USA
Time Type Title of Paper Speaker & Affiliation
9:00-9:45 Invited SYNCHROTRON X-RAY POWDER DIFFRACTION: APPLICATIONS IN MACROMOLECULAR CRYSTALLOGRAPHY Irene Margiolaki, European Synchrotron Radiation Facility(ESRF), Grenoble, France
9:45-10:30 Invited MICRO-SAMPLE X-RAY POWDER DIFFRACTION. APPLICATIONS IN THE PHARMACEUTICAL SCIENCES. Joseph Reibenspies, Texas A & M University, College Station, Texas, USA
10:30-10:50 Break    
10:50-11:35 Invited PAT: ANALYSIS OF PROCESS INDUCED DISORDER OF API BY X-RAY POWDER DIFFRACTION Simon Bates, SSCI, Inc., West Lafayette, Indiana, USA
11:35-12:15   Q&A/Closing Remarks  


Instructors :
Chair: Dr. Jun Han
, Novartis Institutes for Biomedical Research, Inc., Cambridge, MA, USA
Dr. Detlef Beckers, PANalytical, Almelo, The Netherlands
Dr. Harry G. Brittain, Center for Pharmaceutical Physics, Milford, NJ, USA
Dr. John Faber, International Centre for Diffraction Data, Newtown Square, PA, USA
Dr. Raj Suryanarayanan, University of Minnesota, MN, USA
Dr. Shawn Yin, Bristol-Myers Squibb Company, New Brunswick, NJ, USA

Morning Basic Theories and Concepts (Monday 13 February - 8:15AM - 12PM)
Time Workshop Instructor
8:15 - 9:00 Basics of crystal structure and X-ray diffractometry Dr. Detlef Beckers
9:00 - 9:45 Techniques of Powder X-ray Diffractometry - Instrumentation and Optimization Dr. Detlef Beckers
9:45 - 10:00 BREAK  
10:00 - 10:55 Basics of Pharmaceutical Solids Dr. Harry G. Brittain
10:55 - 12:00 Round table and Q&A for Basic theories and Concepts All instructors

Afternoon Applications and Case Studies (Monday 13 February - 1PM - 5:30PM)
Time Workshop Instructor
1:00 - 1:35 Indexing and structure solution from powder XRD data Dr. John Faber
1:35 - 2:45 Polymorphs Analysis - Qualitative and quantitative analysis of both API and Finished Products Dr. Shawn Yin and Dr. Detlef Beckers
2:45 - 3:00 BREAK  
3:00 - 3:50 Application of variable temperature and humidity (environmental) PXRD in Characterizing Pharmaceutical solids Dr. Shawn Yin and Dr. Jun Han
3:50 - 4:35 Characterization of amorphous and crystalline phases by PXRD Dr. Harry G. Brittain
4:35 - 5:30 Round table and Q&A for Application and Case Studies All instructors

 

Scientific Organizing Committee
Dr. John Faber, Chair, International Centre for Diffraction Data , Newtown Square, PA , U.SA
Dr. Detlef Beckers, PANalytical , Almelo , The Netherlands
Dr. Harry G. Brittain, Center for Pharmaceutical Physics , Milford , NJ , U.S.A.
Dr. Julien Giovannini , AstraZeneca , Lund , Sweden
Dr. Jun Han, Novartis Institutes for Biomedical Research , Inc., Cambridge , MA , U.S.A.
Dr. Arnt Kern, Bruker AXS GmbH , Karlsruhe , Germany
Dr. Fangling Needham, International Centre for Diffraction Data , Newtown Square, PA , U.S.A.
Dr. Kenneth Shankland, Rutherford Appleton Laboratory, Oxon , U.K.
Dr. Peter W. Stephens, State University of New York , Stony Brook , NY , U.S.A.
Dr. Gregory A. Stephenson, Eli Lilly and Company , Indianapolis , IN , U.S.A.
Dr. Raj Suryanarayanan, University of Minnesota , Minneapolis , MN , U.S.A.
Dr. Peter G. Varlashkin, Metrics, Inc., Greenville , NC , U.S.A.
Dr. Shawn Yin, Bristol-Myers Squibb Company , New Brunswick , NJ , U.S.A.

Location:

Marriott Somerset
110 Davidson Avenue
Somerset , New Jersey 08873
Tel: +(732) 560-0500
Reservations: +(800) 238-3198
Web: www.marriott.com
For more information on New Jersey visit: http://www.state.nj.us/travel/

Online Reservations Instructions for Somerset Marriott:

  1. Go to www.marriott.com/sosnj
  2. Scroll down and on the right hand side enter your arrival and departure dates
  3. Below that you will see a section for optional information, you can enter your rewards number in the designated box
  4. Go to the box labeled Group Code located under the Corporate / Promotional Code box and enter "ICDICDA"
  5. Select "Find" - and then select our promotional rate of $104 USD

Symposium Format:
One-day optional workshop followed by three-day symposium
Manufacturer Exhibition
Poster Session and reception
The symposium talks will be presented in English.

General Information:
Attire: Attire is informal for most activities
Climate: 42 F
Time Zone: Eastern Standard Time (EST)

Accommodations & Travel:

Accommodations:
A block of rooms is reserved for symposium participants at the Somerset Marriott, 110 Davidson Avenue , Somerset , NJ 08873 . U.S.A. . Web site: www.marriott.com, Telephone: +(732) 560-0500, Reservations: +(800) 238-3198. The group rate at the hotels is $104.00 per room plus state and local taxes. To make your reservation, please contact the hotel and reference the group name: PPXRD or International Centre for Diffraction Data to receive the discounted group rate. The deadline for hotel reservations is 22 January 2006. You will not be guaranteed a room after that time. Please contact the hotel for the policy on cancellation of reservations.

Getting to Marriott Somerset , New Jersey U.S.A. :

By Air
Airport: Newark - EWR
Tel: +973-961-6000
Hotel Direction: 28 mi NE
Directions from Airport: Take NJ Turnpike South to Exit 10- I-287 North to Exit 10 ( Easton Ave ) to first light, go left on Davidson Ave
Estimated taxi fare: 80 USD (one way)

By Train
New Brunswick Station (20 mi SE)

By Car
Use this Marriott link to obtain detailed directions from your location to the Marriott Somerset: http://marriott.com/property/mapandnearbyairports/drivingdirections.mi?marshaCode=sosnj

Parking: Complimentary

More Information:

Cancellation Policy:
A 50% refund will be issued, if the cancellation is received by the ICDD in writing no later than 15 January 2006. No refunds will be issued for cancellations received after that date, however, you may transfer your registration to a colleague with advance notice.

Exhibitor Information:
A commercial exhibition of analytical instrumentation and related products and services is planned during the symposium and during the evening poster session and reception. Organizations interested in exhibiting or sponsorship opportunities, please contact Leah Mooney at mooney@icdd.com or Tel: +610-325-9814.

Sponsorships:
Opportunities for sponsorship are available to increase your presence at PPXRD. These opportunities include sponsoring or co-sponsoring the evening reception and poster session or daily coffee breaks. The sponsor of the evening reception and poster session will receive first choice of exhibit location, banner on the PPXRD web page with link to your web site, link to your web site from our electronic e-mail marketing campaigns and space to place a full-page advertisement in the symposium Book of Abstracts.

 

READ THE PPXRD-4 SYMPOSIUM SUMMARY

The International Centre for Diffraction Data was proud to present the 4th PPXRD in the spectacular city of Barcelona, Spain located on the Mediterranean Sea. This symposium was designed to create a forum for discussion and the exchange of knowledge and cutting edge ideas among those interested in the combined fields of XRD and the pharmaceutical industry. These pages are maintained for archival purposes - the Symposium was a great success. .

Information on Past PPXRD Symposiums
PPXRD-4, February 21-24, 2005
PPXRD-3, February 23-25, 2004
PPXRD-2, December 9-12, 2002
PPXRD-1 - September 27-29, 1999

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